| Ascoli Piceno to Savona | 274.47 mi (441.72 km) |
| Ascoli Piceno to Scafati | 152.75 mi (245.83 km) |
| Ascoli Piceno to Scalea | 239.04 mi (384.69 km) |
| Ascoli Piceno to Scandiano | 188.13 mi (302.76 km) |
| Ascoli Piceno to Scandicci | 135.62 mi (218.25 km) |
| Ascoli Piceno to Schio | 226.30 mi (364.19 km) |
| Ascoli Piceno to Sciacca | 369.93 mi (595.35 km) |
| Ascoli Piceno to Scicli | 422.79 mi (680.41 km) |
| Ascoli Piceno to Scordia | 389.26 mi (626.45 km) |
| Ascoli Piceno to Scorze | 201.73 mi (324.66 km) |
| Ascoli Piceno to Sedico | 237.24 mi (381.81 km) |
| Ascoli Piceno to Sedriano | 292.24 mi (470.32 km) |
| Ascoli Piceno to Segni | 85.66 mi (137.85 km) |
| Ascoli Piceno to Segrate | 279.98 mi (450.59 km) |
| Ascoli Piceno to Selargius | 338.79 mi (545.23 km) |
