| Ascoli Piceno to Settimo Torinese | 329.26 mi (529.89 km) |
| Ascoli Piceno to Seveso | 292.61 mi (470.92 km) |
| Ascoli Piceno to Sezze | 96.95 mi (156.03 km) |
| Ascoli Piceno to Siano | 152.59 mi (245.58 km) |
| Ascoli Piceno to Siena | 118.15 mi (190.14 km) |
| Ascoli Piceno to Signa | 140.50 mi (226.11 km) |
| Ascoli Piceno to Silea | 203.97 mi (328.26 km) |
| Ascoli Piceno to Silvi Paese | 34.11 mi (54.89 km) |
| Ascoli Piceno to Sinalunga | 96.80 mi (155.79 km) |
| Ascoli Piceno to Siniscola | 254.74 mi (409.96 km) |
| Ascoli Piceno to Sinnai | 334.75 mi (538.73 km) |
| Ascoli Piceno to Siracusa | 409.46 mi (658.96 km) |
| Ascoli Piceno to Solaro | 293.37 mi (472.13 km) |
| Ascoli Piceno to Soliera | 186.00 mi (299.33 km) |
| Ascoli Piceno to Solofra | 153.84 mi (247.58 km) |
