| Ascoli Piceno to Somma Lombardo | 310.87 mi (500.29 km) |
| Ascoli Piceno to Somma Vesuviana | 143.52 mi (230.97 km) |
| Ascoli Piceno to Sommacampagna | 222.27 mi (357.72 km) |
| Ascoli Piceno to Sona | 224.58 mi (361.43 km) |
| Ascoli Piceno to Sondrio | 293.33 mi (472.07 km) |
| Ascoli Piceno to Sora | 78.32 mi (126.05 km) |
| Ascoli Piceno to Sorbolo | 208.35 mi (335.31 km) |
| Ascoli Piceno to Soresina | 250.07 mi (402.45 km) |
| Ascoli Piceno to Sorisole | 278.35 mi (447.97 km) |
| Ascoli Piceno to Sorrento | 158.85 mi (255.65 km) |
| Ascoli Piceno to Sorso | 294.09 mi (473.29 km) |
| Ascoli Piceno to Sortino | 400.09 mi (643.88 km) |
| Ascoli Piceno to Soverato Marina | 327.03 mi (526.30 km) |
| Ascoli Piceno to Sovicille | 122.34 mi (196.88 km) |
| Ascoli Piceno to Spello | 47.09 mi (75.78 km) |
