| Ascoli Piceno to Spilamberto | 173.10 mi (278.57 km) |
| Ascoli Piceno to Spilimbergo | 229.09 mi (368.69 km) |
| Ascoli Piceno to Spinea | 195.75 mi (315.03 km) |
| Ascoli Piceno to Spoleto | 45.97 mi (73.98 km) |
| Ascoli Piceno to Spoltore | 39.30 mi (63.25 km) |
| Ascoli Piceno to Spresiano | 213.11 mi (342.97 km) |
| Ascoli Piceno to Squinzano | 284.67 mi (458.13 km) |
| Ascoli Piceno to Statte | 244.27 mi (393.12 km) |
| Ascoli Piceno to Stezzano | 274.32 mi (441.48 km) |
| Ascoli Piceno to Strada | 124.87 mi (200.95 km) |
| Ascoli Piceno to Stradella | 262.96 mi (423.20 km) |
| Ascoli Piceno to Striano | 149.33 mi (240.32 km) |
| Ascoli Piceno to Subiaco | 67.97 mi (109.39 km) |
| Ascoli Piceno to Sulmona | 58.10 mi (93.51 km) |
| Ascoli Piceno to Surbo | 289.55 mi (465.98 km) |
