| Astoria to Oswego (Illinois) | 1,776.67 mi (2,859.28 km) |
| Astoria to Oswego (New York) | 2,291.65 mi (3,688.06 km) |
| Astoria to Otsego (Minnesota) | 1,448.53 mi (2,331.19 km) |
| Astoria to Ottawa (Illinois) | 1,761.98 mi (2,835.63 km) |
| Astoria to Ottawa (Kansas) | 1,537.84 mi (2,474.91 km) |
| Astoria to Ottumwa (Iowa) | 1,599.26 mi (2,573.76 km) |
| Astoria to Overland (Missouri) | 1,766.86 mi (2,843.48 km) |
| Astoria to Overland Park (Kansas) | 1,555.52 mi (2,503.37 km) |
| Astoria to Overlea (Maryland) | 2,407.30 mi (3,874.17 km) |
| Astoria to Oviedo (Florida) | 2,592.53 mi (4,172.28 km) |
| Astoria to Owasso (Oklahoma) | 1,595.14 mi (2,567.12 km) |
| Astoria to Owatonna (Minnesota) | 1,487.85 mi (2,394.47 km) |
| Astoria to Owensboro (Kentucky) | 1,952.91 mi (3,142.90 km) |
| Astoria to Owings Mills (Maryland) | 2,392.79 mi (3,850.82 km) |
| Astoria to Owosso (Michigan) | 1,941.92 mi (3,125.21 km) |
