| Astoria to Sanford (Maine) | 2,558.75 mi (4,117.91 km) |
| Astoria to Sanford (North Carolina) | 2,411.81 mi (3,881.43 km) |
| Astoria to Sanger (California) | 691.12 mi (1,112.26 km) |
| Astoria to Santa Ana (California) | 914.87 mi (1,472.35 km) |
| Astoria to Santa Barbara (California) | 840.06 mi (1,351.94 km) |
| Astoria to Santa Clara (California) | 616.73 mi (992.53 km) |
| Astoria to Santa Clara (Oregon) | 146.72 mi (236.13 km) |
| Astoria to Santa Clarita (California) | 859.35 mi (1,383.00 km) |
| Astoria to Santa Cruz (California) | 642.62 mi (1,034.20 km) |
| Astoria to Santa Fe (New Mexico) | 1,176.24 mi (1,892.98 km) |
| Astoria to Santa Fe (Texas) | 1,932.47 mi (3,110.00 km) |
| Astoria to Santa Fe Springs (California) | 898.77 mi (1,446.44 km) |
| Astoria to Santa Maria (California) | 797.04 mi (1,282.70 km) |
| Astoria to Santa Monica (California) | 885.64 mi (1,425.30 km) |
| Astoria to Santa Paula (California) | 854.37 mi (1,374.97 km) |
