| Astoria to Scottsboro (Alabama) | 2,115.96 mi (3,405.31 km) |
| Astoria to Scottsdale (Arizona) | 1,067.86 mi (1,718.56 km) |
| Astoria to Scranton (Pennsylvania) | 2,386.29 mi (3,840.36 km) |
| Astoria to Seabrook (Maryland) | 2,403.63 mi (3,868.27 km) |
| Astoria to Seabrook (Texas) | 1,926.70 mi (3,100.73 km) |
| Astoria to Seaford (New York) | 2,510.41 mi (4,040.12 km) |
| Astoria to Seagoville (Texas) | 1,716.14 mi (2,761.86 km) |
| Astoria to Seal Beach (California) | 910.37 mi (1,465.11 km) |
| Astoria to Searcy (Arkansas) | 1,825.71 mi (2,938.19 km) |
| Astoria to Seaside (California) | 668.65 mi (1,076.10 km) |
| Astoria to SeaTac (Washington) | 112.42 mi (180.93 km) |
| Astoria to Seattle (Washington) | 121.34 mi (195.28 km) |
| Astoria to Sebastian (Florida) | 2,664.33 mi (4,287.82 km) |
| Astoria to Sebring (Florida) | 2,632.94 mi (4,237.31 km) |
| Astoria to Secaucus (New Jersey) | 2,479.96 mi (3,991.11 km) |
