| Astoria to Southern Pines (North Carolina) | 2,411.75 mi (3,881.33 km) |
| Astoria to Southfield (Michigan) | 1,998.12 mi (3,215.67 km) |
| Astoria to Southgate (Michigan) | 2,007.66 mi (3,231.02 km) |
| Astoria to Southlake (Texas) | 1,675.96 mi (2,697.20 km) |
| Astoria to Spanaway (Washington) | 90.94 mi (146.36 km) |
| Astoria to Spanish Fork (Utah) | 741.83 mi (1,193.86 km) |
| Astoria to Spanish Lake (Missouri) | 1,771.58 mi (2,851.09 km) |
| Astoria to Spanish Springs (Nevada) | 497.09 mi (799.99 km) |
| Astoria to Sparks (Nevada) | 501.39 mi (806.91 km) |
| Astoria to Spartanburg (South Carolina) | 2,300.57 mi (3,702.40 km) |
| Astoria to Spearfish (South Dakota) | 975.25 mi (1,569.52 km) |
| Astoria to Speedway (Indiana) | 1,929.66 mi (3,105.48 km) |
| Astoria to Spencer (Iowa) | 1,415.63 mi (2,278.24 km) |
| Astoria to Spokane (Washington) | 317.52 mi (511.00 km) |
| Astoria to Spokane Valley (Washington) | 326.30 mi (525.13 km) |
