| Big Spring to Oswego (Illinois) | 973.78 mi (1,567.14 km) |
| Big Spring to Oswego (New York) | 1,558.78 mi (2,508.61 km) |
| Big Spring to Otsego (Minnesota) | 993.54 mi (1,598.95 km) |
| Big Spring to Ottawa (Illinois) | 939.90 mi (1,512.63 km) |
| Big Spring to Ottawa (Kansas) | 561.52 mi (903.67 km) |
| Big Spring to Ottumwa (Iowa) | 786.76 mi (1,266.17 km) |
| Big Spring to Overland (Missouri) | 767.17 mi (1,234.64 km) |
| Big Spring to Overland Park (Kansas) | 596.90 mi (960.62 km) |
| Big Spring to Overlea (Maryland) | 1,477.14 mi (2,377.23 km) |
| Big Spring to Oviedo (Florida) | 1,231.79 mi (1,982.37 km) |
| Big Spring to Owasso (Oklahoma) | 426.82 mi (686.90 km) |
| Big Spring to Owatonna (Minnesota) | 932.33 mi (1,500.43 km) |
| Big Spring to Owensboro (Kentucky) | 896.56 mi (1,442.87 km) |
| Big Spring to Owings Mills (Maryland) | 1,463.51 mi (2,355.29 km) |
| Big Spring to Owosso (Michigan) | 1,199.72 mi (1,930.76 km) |
