| Big Spring to Santa Rosa (California) | 1,267.33 mi (2,039.57 km) |
| Big Spring to Santaquin (Utah) | 784.40 mi (1,262.37 km) |
| Big Spring to Santee (California) | 903.25 mi (1,453.64 km) |
| Big Spring to Sapulpa (Oklahoma) | 403.03 mi (648.61 km) |
| Big Spring to Saraland (Alabama) | 793.15 mi (1,276.46 km) |
| Big Spring to Sarasota (Florida) | 1,183.02 mi (1,903.89 km) |
| Big Spring to Sarasota Springs (Florida) | 1,187.69 mi (1,911.41 km) |
| Big Spring to Saratoga (California) | 1,214.20 mi (1,954.06 km) |
| Big Spring to Saratoga Springs (New York) | 1,679.35 mi (2,702.64 km) |
| Big Spring to Saratoga Springs (Utah) | 805.99 mi (1,297.12 km) |
| Big Spring to Sartell (Minnesota) | 1,002.37 mi (1,613.15 km) |
| Big Spring to Satellite Beach (Florida) | 1,275.58 mi (2,052.85 km) |
| Big Spring to Sauk Rapids (Minnesota) | 1,002.46 mi (1,613.30 km) |
| Big Spring to Sault Ste. Marie (Michigan) | 1,337.20 mi (2,152.01 km) |
| Big Spring to Savage (Minnesota) | 968.54 mi (1,558.72 km) |
