| Big Spring to Scottsboro (Alabama) | 904.09 mi (1,454.99 km) |
| Big Spring to Scottsdale (Arizona) | 610.02 mi (981.73 km) |
| Big Spring to Scranton (Pennsylvania) | 1,554.18 mi (2,501.21 km) |
| Big Spring to Seabrook (Maryland) | 1,454.44 mi (2,340.69 km) |
| Big Spring to Seabrook (Texas) | 424.59 mi (683.31 km) |
| Big Spring to Seaford (New York) | 1,652.18 mi (2,658.93 km) |
| Big Spring to Seagoville (Texas) | 289.10 mi (465.26 km) |
| Big Spring to Seal Beach (California) | 966.08 mi (1,554.76 km) |
| Big Spring to Searcy (Arkansas) | 596.76 mi (960.40 km) |
| Big Spring to Seaside (California) | 1,195.51 mi (1,923.99 km) |
| Big Spring to SeaTac (Washington) | 1,515.20 mi (2,438.47 km) |
| Big Spring to Seattle (Washington) | 1,523.43 mi (2,451.73 km) |
| Big Spring to Sebastian (Florida) | 1,291.16 mi (2,077.92 km) |
| Big Spring to Sebring (Florida) | 1,242.20 mi (1,999.13 km) |
| Big Spring to Secaucus (New Jersey) | 1,624.45 mi (2,614.30 km) |
