| Big Spring to Southern Pines (North Carolina) | 1,282.32 mi (2,063.70 km) |
| Big Spring to Southfield (Michigan) | 1,221.10 mi (1,965.17 km) |
| Big Spring to Southgate (Michigan) | 1,214.45 mi (1,954.47 km) |
| Big Spring to Southlake (Texas) | 256.81 mi (413.29 km) |
| Big Spring to Spanaway (Washington) | 1,505.88 mi (2,423.48 km) |
| Big Spring to Spanish Fork (Utah) | 784.41 mi (1,262.39 km) |
| Big Spring to Spanish Lake (Missouri) | 777.90 mi (1,251.91 km) |
| Big Spring to Spanish Springs (Nevada) | 1,136.26 mi (1,828.63 km) |
| Big Spring to Sparks (Nevada) | 1,136.52 mi (1,829.06 km) |
| Big Spring to Spartanburg (South Carolina) | 1,138.99 mi (1,833.02 km) |
| Big Spring to Spearfish (South Dakota) | 855.83 mi (1,377.33 km) |
| Big Spring to Speedway (Indiana) | 996.44 mi (1,603.61 km) |
| Big Spring to Spencer (Iowa) | 828.61 mi (1,333.52 km) |
| Big Spring to Spokane (Washington) | 1,354.59 mi (2,180.00 km) |
| Big Spring to Spokane Valley (Washington) | 1,347.99 mi (2,169.38 km) |
