| Big Spring to Storm Lake (Iowa) | 796.65 mi (1,282.08 km) |
| Big Spring to Storrs (Connecticut) | 1,731.96 mi (2,787.31 km) |
| Big Spring to Stoughton (Wisconsin) | 995.59 mi (1,602.24 km) |
| Big Spring to Stow (Ohio) | 1,266.11 mi (2,037.60 km) |
| Big Spring to Streamwood (Illinois) | 994.63 mi (1,600.71 km) |
| Big Spring to Streator (Illinois) | 930.01 mi (1,496.70 km) |
| Big Spring to Streetsboro (Ohio) | 1,272.05 mi (2,047.17 km) |
| Big Spring to Strongsville (Ohio) | 1,250.88 mi (2,013.10 km) |
| Big Spring to Stuart (Florida) | 1,318.51 mi (2,121.93 km) |
| Big Spring to Stuarts Draft (Virginia) | 1,325.83 mi (2,133.72 km) |
| Big Spring to Sturgis (Michigan) | 1,102.09 mi (1,773.65 km) |
| Big Spring to Suamico (Wisconsin) | 1,119.63 mi (1,801.87 km) |
| Big Spring to Sudley (Virginia) | 1,417.78 mi (2,281.70 km) |
| Big Spring to Suffern (New York) | 1,625.72 mi (2,616.34 km) |
| Big Spring to Suffolk (Virginia) | 1,443.75 mi (2,323.49 km) |
