| Cape Girardeau to Sacile | 4,927.78 mi (7,930.50 km) |
| Cape Girardeau to Sala Consilina | 5,281.52 mi (8,499.79 km) |
| Cape Girardeau to Salemi | 5,270.52 mi (8,482.08 km) |
| Cape Girardeau to Salerno | 5,234.74 mi (8,424.49 km) |
| Cape Girardeau to Salo | 4,863.76 mi (7,827.47 km) |
| Cape Girardeau to Salsomaggiore Terme | 4,871.47 mi (7,839.87 km) |
| Cape Girardeau to Saluzzo | 4,775.41 mi (7,685.27 km) |
| Cape Girardeau to Salzano | 4,929.67 mi (7,933.54 km) |
| Cape Girardeau to Samarate | 4,792.41 mi (7,712.63 km) |
| Cape Girardeau to San Benedetto del Tronto | 5,104.57 mi (8,215.02 km) |
| Cape Girardeau to San Biagio di Callalta | 4,934.14 mi (7,940.73 km) |
| Cape Girardeau to San Bonifacio | 4,901.60 mi (7,888.36 km) |
| Cape Girardeau to San Casciano in Val di Pesa | 4,965.82 mi (7,991.71 km) |
| Cape Girardeau to San Cataldo | 5,336.00 mi (8,587.46 km) |
| Cape Girardeau to San Cesareo | 5,106.21 mi (8,217.65 km) |
