| Cape Girardeau to Sestu | 5,048.13 mi (8,124.18 km) |
| Cape Girardeau to Settimo Torinese | 4,768.79 mi (7,674.62 km) |
| Cape Girardeau to Seveso | 4,805.78 mi (7,734.15 km) |
| Cape Girardeau to Sezze | 5,130.23 mi (8,256.31 km) |
| Cape Girardeau to Siano | 5,226.91 mi (8,411.90 km) |
| Cape Girardeau to Siena | 4,985.16 mi (8,022.84 km) |
| Cape Girardeau to Signa | 4,957.33 mi (7,978.05 km) |
| Cape Girardeau to Silea | 4,932.04 mi (7,937.35 km) |
| Cape Girardeau to Silvi Paese | 5,130.53 mi (8,256.78 km) |
| Cape Girardeau to Sinalunga | 5,005.75 mi (8,055.97 km) |
| Cape Girardeau to Siniscola | 5,024.29 mi (8,085.82 km) |
| Cape Girardeau to Sinnai | 5,052.89 mi (8,131.84 km) |
| Cape Girardeau to Siracusa | 5,410.15 mi (8,706.80 km) |
| Cape Girardeau to Solaro | 4,804.67 mi (7,732.37 km) |
| Cape Girardeau to Soliera | 4,912.87 mi (7,906.50 km) |
