| Cape Girardeau to Spello | 5,053.47 mi (8,132.78 km) |
| Cape Girardeau to Spilamberto | 4,924.59 mi (7,925.36 km) |
| Cape Girardeau to Spilimbergo | 4,936.54 mi (7,944.60 km) |
| Cape Girardeau to Spinea | 4,933.00 mi (7,938.89 km) |
| Cape Girardeau to Spoleto | 5,063.40 mi (8,148.75 km) |
| Cape Girardeau to Spoltore | 5,135.39 mi (8,264.61 km) |
| Cape Girardeau to Spresiano | 4,925.13 mi (7,926.22 km) |
| Cape Girardeau to Squinzano | 5,380.95 mi (8,659.81 km) |
| Cape Girardeau to Statte | 5,340.42 mi (8,594.57 km) |
| Cape Girardeau to Stezzano | 4,826.35 mi (7,767.26 km) |
| Cape Girardeau to Strada | 4,974.10 mi (8,005.04 km) |
| Cape Girardeau to Stradella | 4,833.52 mi (7,778.79 km) |
| Cape Girardeau to Striano | 5,221.00 mi (8,402.39 km) |
| Cape Girardeau to Subiaco | 5,113.93 mi (8,230.08 km) |
| Cape Girardeau to Sulmona | 5,143.39 mi (8,277.48 km) |
