| Cape Girardeau to Sangeorgiu de Mures | 5,351.11 mi (8,611.78 km) |
| Cape Girardeau to Sangeorz-Bai | 5,320.75 mi (8,562.92 km) |
| Cape Girardeau to Sannicolau Mare | 5,233.71 mi (8,422.84 km) |
| Cape Girardeau to Santana | 5,253.60 mi (8,454.85 km) |
| Cape Girardeau to Satu Mare | 5,238.93 mi (8,431.24 km) |
| Cape Girardeau to Scobinti | 5,397.72 mi (8,686.78 km) |
| Cape Girardeau to Scornicesti | 5,445.80 mi (8,764.16 km) |
| Cape Girardeau to Sebes | 5,346.22 mi (8,603.90 km) |
| Cape Girardeau to Seini | 5,254.72 mi (8,456.66 km) |
| Cape Girardeau to Sfantu-Gheorghe | 5,429.73 mi (8,738.30 km) |
| Cape Girardeau to Sibiu | 5,374.81 mi (8,649.92 km) |
| Cape Girardeau to Sighetu Marmatiei | 5,267.72 mi (8,477.57 km) |
| Cape Girardeau to Sighisoara | 5,378.00 mi (8,655.06 km) |
| Cape Girardeau to Simeria | 5,331.00 mi (8,579.42 km) |
| Cape Girardeau to Sinaia | 5,445.46 mi (8,763.63 km) |
