| Cape Girardeau to Santa Ursula | 4,180.98 mi (6,728.63 km) |
| Cape Girardeau to Santander | 4,327.52 mi (6,964.47 km) |
| Cape Girardeau to Santany | 4,779.51 mi (7,691.88 km) |
| Cape Girardeau to Santiago de Compostela | 4,129.75 mi (6,646.19 km) |
| Cape Girardeau to Santiago del Teide | 4,168.17 mi (6,708.02 km) |
| Cape Girardeau to Santiponce | 4,415.83 mi (7,106.59 km) |
| Cape Girardeau to Santomera | 4,632.53 mi (7,455.33 km) |
| Cape Girardeau to Santona | 4,343.74 mi (6,990.58 km) |
| Cape Girardeau to Santurce-Antiguo | 4,366.29 mi (7,026.86 km) |
| Cape Girardeau to Sarria | 4,184.33 mi (6,734.02 km) |
| Cape Girardeau to Sauzal | 4,182.12 mi (6,730.47 km) |
| Cape Girardeau to Sedavi | 4,616.02 mi (7,428.77 km) |
| Cape Girardeau to Segorbe | 4,596.53 mi (7,397.39 km) |
| Cape Girardeau to Segovia | 4,392.75 mi (7,069.44 km) |
| Cape Girardeau to Senmanat | 4,654.28 mi (7,490.33 km) |
