| Cape Girardeau to Shoreham-by-Sea | 4,253.53 mi (6,845.40 km) |
| Cape Girardeau to Shotley Bridge | 4,080.83 mi (6,567.47 km) |
| Cape Girardeau to Shrewsbury | 4,104.00 mi (6,604.76 km) |
| Cape Girardeau to Sidcup | 4,250.81 mi (6,841.02 km) |
| Cape Girardeau to Sidmouth | 4,139.82 mi (6,662.40 km) |
| Cape Girardeau to Sileby | 4,166.76 mi (6,705.75 km) |
| Cape Girardeau to Sittingbourne | 4,278.21 mi (6,885.11 km) |
| Cape Girardeau to Skegness | 4,210.17 mi (6,775.61 km) |
| Cape Girardeau to Skelmersdale | 4,080.95 mi (6,567.65 km) |
| Cape Girardeau to Skipton | 4,098.81 mi (6,596.40 km) |
| Cape Girardeau to Sleaford | 4,185.76 mi (6,736.33 km) |
| Cape Girardeau to Slough | 4,221.48 mi (6,793.81 km) |
| Cape Girardeau to Small Heath | 4,145.39 mi (6,671.36 km) |
| Cape Girardeau to Smethwick | 4,140.15 mi (6,662.92 km) |
| Cape Girardeau to Snaresbrook | 4,242.68 mi (6,827.93 km) |
