| Cape Girardeau to Abilene (Texas) | 666.83 mi (1,073.15 km) |
| Cape Girardeau to Accokeek (Maryland) | 689.67 mi (1,109.92 km) |
| Cape Girardeau to Acworth (Georgia) | 354.61 mi (570.68 km) |
| Cape Girardeau to Ada (Oklahoma) | 434.17 mi (698.73 km) |
| Cape Girardeau to Addison (Illinois) | 329.72 mi (530.64 km) |
| Cape Girardeau to Addison (Texas) | 509.07 mi (819.27 km) |
| Cape Girardeau to Adelanto (California) | 1,565.13 mi (2,518.84 km) |
| Cape Girardeau to Adelphi (Maryland) | 693.59 mi (1,116.22 km) |
| Cape Girardeau to Adrian (Michigan) | 431.90 mi (695.07 km) |
| Cape Girardeau to Affton (Missouri) | 95.26 mi (153.30 km) |
| Cape Girardeau to Agoura Hills (California) | 1,645.70 mi (2,648.50 km) |
| Cape Girardeau to Aguadilla (Puerto Rico) | 1,880.54 mi (3,026.44 km) |
| Cape Girardeau to Aiken (South Carolina) | 512.30 mi (824.47 km) |
| Cape Girardeau to Akron (Ohio) | 502.73 mi (809.06 km) |
| Cape Girardeau to Alabaster (Alabama) | 322.05 mi (518.29 km) |
