| Cape Girardeau to Alderwood Manor (Washington) | 1,798.58 mi (2,894.54 km) |
| Cape Girardeau to Aldine (Texas) | 610.76 mi (982.93 km) |
| Cape Girardeau to Alexander City (Alabama) | 365.80 mi (588.70 km) |
| Cape Girardeau to Alexandria (Louisiana) | 447.73 mi (720.55 km) |
| Cape Girardeau to Alexandria (Minnesota) | 663.40 mi (1,067.63 km) |
| Cape Girardeau to Alexandria (Virginia) | 685.93 mi (1,103.90 km) |
| Cape Girardeau to Algonquin (Illinois) | 341.68 mi (549.88 km) |
| Cape Girardeau to Alhambra (California) | 1,612.62 mi (2,595.27 km) |
| Cape Girardeau to Alice (Texas) | 824.60 mi (1,327.06 km) |
| Cape Girardeau to Aliso Viejo (California) | 1,600.34 mi (2,575.50 km) |
| Cape Girardeau to Allen (Texas) | 495.30 mi (797.11 km) |
| Cape Girardeau to Allen Park (Michigan) | 479.87 mi (772.28 km) |
| Cape Girardeau to Allendale (Michigan) | 435.80 mi (701.35 km) |
| Cape Girardeau to Allentown (Pennsylvania) | 789.04 mi (1,269.84 km) |
| Cape Girardeau to Alliance (Ohio) | 516.03 mi (830.48 km) |
