| Cape Girardeau to Altus (Oklahoma) | 574.61 mi (924.75 km) |
| Cape Girardeau to Alum Rock (California) | 1,763.58 mi (2,838.20 km) |
| Cape Girardeau to Alvin (Texas) | 639.40 mi (1,029.01 km) |
| Cape Girardeau to Amarillo (Texas) | 698.61 mi (1,124.30 km) |
| Cape Girardeau to Amelia (Ohio) | 313.20 mi (504.04 km) |
| Cape Girardeau to American Canyon (California) | 1,778.19 mi (2,861.72 km) |
| Cape Girardeau to American Fork (Utah) | 1,211.85 mi (1,950.28 km) |
| Cape Girardeau to Americus (Georgia) | 471.83 mi (759.33 km) |
| Cape Girardeau to Ames (Iowa) | 390.77 mi (628.88 km) |
| Cape Girardeau to Amherst (Ohio) | 482.65 mi (776.75 km) |
| Cape Girardeau to Ammon (Idaho) | 1,248.49 mi (2,009.25 km) |
| Cape Girardeau to Amsterdam (New York) | 898.52 mi (1,446.03 km) |
| Cape Girardeau to Anacortes (Washington) | 1,824.70 mi (2,936.57 km) |
| Cape Girardeau to Anaheim (California) | 1,602.14 mi (2,578.40 km) |
| Cape Girardeau to Anchorage (Alaska) | 3,005.39 mi (4,836.71 km) |
