| Cape Girardeau to Anderson (California) | 1,763.83 mi (2,838.61 km) |
| Cape Girardeau to Anderson (Indiana) | 283.50 mi (456.25 km) |
| Cape Girardeau to Anderson (South Carolina) | 431.98 mi (695.21 km) |
| Cape Girardeau to Anderson Creek (North Carolina) | 606.74 mi (976.46 km) |
| Cape Girardeau to Andover (Kansas) | 415.96 mi (669.42 km) |
| Cape Girardeau to Andover (Minnesota) | 582.64 mi (937.67 km) |
| Cape Girardeau to Andrews (Texas) | 812.67 mi (1,307.86 km) |
| Cape Girardeau to Angleton (Texas) | 656.35 mi (1,056.30 km) |
| Cape Girardeau to Ankeny (Iowa) | 373.55 mi (601.18 km) |
| Cape Girardeau to Ann Arbor (Michigan) | 461.75 mi (743.12 km) |
| Cape Girardeau to Anna (Texas) | 479.67 mi (771.96 km) |
| Cape Girardeau to Annandale (Virginia) | 680.12 mi (1,094.55 km) |
| Cape Girardeau to Annapolis (Maryland) | 717.99 mi (1,155.49 km) |
| Cape Girardeau to Annapolis Neck (Maryland) | 718.08 mi (1,155.63 km) |
| Cape Girardeau to Anniston (Alabama) | 328.04 mi (527.94 km) |
