| Cape Girardeau to Anoka (Minnesota) | 580.70 mi (934.55 km) |
| Cape Girardeau to Ansonia (Connecticut) | 922.68 mi (1,484.92 km) |
| Cape Girardeau to Antelope (California) | 1,725.18 mi (2,776.41 km) |
| Cape Girardeau to Anthem (Arizona) | 1,286.57 mi (2,070.53 km) |
| Cape Girardeau to Antioch (California) | 1,755.35 mi (2,824.97 km) |
| Cape Girardeau to Antioch (Illinois) | 365.34 mi (587.96 km) |
| Cape Girardeau to Apache Junction (Arizona) | 1,264.40 mi (2,034.86 km) |
| Cape Girardeau to Apex (North Carolina) | 603.05 mi (970.51 km) |
| Cape Girardeau to Apollo Beach (Florida) | 779.91 mi (1,255.14 km) |
| Cape Girardeau to Apopka (Florida) | 754.45 mi (1,214.18 km) |
| Cape Girardeau to Apple Valley (California) | 1,553.39 mi (2,499.95 km) |
| Cape Girardeau to Apple Valley (Minnesota) | 547.47 mi (881.07 km) |
| Cape Girardeau to Appleton (Wisconsin) | 485.24 mi (780.92 km) |
| Cape Girardeau to Arbutus (Maryland) | 709.94 mi (1,142.53 km) |
| Cape Girardeau to Arcadia (California) | 1,606.26 mi (2,585.03 km) |
