| Cape Girardeau to Arroyo Grande (California) | 1,728.25 mi (2,781.35 km) |
| Cape Girardeau to Artesia (California) | 1,613.83 mi (2,597.22 km) |
| Cape Girardeau to Artesia (New Mexico) | 894.12 mi (1,438.95 km) |
| Cape Girardeau to Artondale (Washington) | 1,808.93 mi (2,911.19 km) |
| Cape Girardeau to Arvada (Colorado) | 858.87 mi (1,382.22 km) |
| Cape Girardeau to Arvin (California) | 1,630.94 mi (2,624.75 km) |
| Cape Girardeau to Asbury Lake (Florida) | 671.54 mi (1,080.74 km) |
| Cape Girardeau to Asbury Park (New Jersey) | 860.17 mi (1,384.32 km) |
| Cape Girardeau to Ashburn (Virginia) | 666.74 mi (1,073.02 km) |
| Cape Girardeau to Asheboro (North Carolina) | 552.10 mi (888.52 km) |
| Cape Girardeau to Asheville (North Carolina) | 407.44 mi (655.71 km) |
| Cape Girardeau to Ashland (California) | 1,775.64 mi (2,857.62 km) |
| Cape Girardeau to Ashland (Kentucky) | 385.23 mi (619.97 km) |
| Cape Girardeau to Ashland (Ohio) | 459.41 mi (739.35 km) |
| Cape Girardeau to Ashland (Oregon) | 1,780.75 mi (2,865.85 km) |
