| Cape Girardeau to Blue Island (Illinois) | 316.58 mi (509.49 km) |
| Cape Girardeau to Blue Springs (Missouri) | 281.66 mi (453.29 km) |
| Cape Girardeau to Bluffdale (Utah) | 1,219.69 mi (1,962.91 km) |
| Cape Girardeau to Bluffton (Indiana) | 334.06 mi (537.61 km) |
| Cape Girardeau to Bluffton (South Carolina) | 602.79 mi (970.10 km) |
| Cape Girardeau to Blythe (California) | 1,428.67 mi (2,299.23 km) |
| Cape Girardeau to Blytheville (Arkansas) | 97.17 mi (156.38 km) |
| Cape Girardeau to Boca Raton (Florida) | 936.19 mi (1,506.65 km) |
| Cape Girardeau to Boerne (Texas) | 740.34 mi (1,191.46 km) |
| Cape Girardeau to Bogalusa (Louisiana) | 451.49 mi (726.61 km) |
| Cape Girardeau to Boiling Springs (South Carolina) | 450.73 mi (725.38 km) |
| Cape Girardeau to Boise (Idaho) | 1,460.69 mi (2,350.76 km) |
| Cape Girardeau to Bolingbrook (Illinois) | 312.38 mi (502.72 km) |
| Cape Girardeau to Bolivar (Missouri) | 212.55 mi (342.06 km) |
| Cape Girardeau to Bon Air (Virginia) | 657.61 mi (1,058.32 km) |
