| Cape Girardeau to Candler-McAfee (Georgia) | 386.84 mi (622.57 km) |
| Cape Girardeau to Caño Martin Peña (Puerto Rico) | 1,929.38 mi (3,105.03 km) |
| Cape Girardeau to Cañon City (Colorado) | 856.62 mi (1,378.60 km) |
| Cape Girardeau to Canóvanas (Puerto Rico) | 1,939.16 mi (3,120.78 km) |
| Cape Girardeau to Canton (Georgia) | 354.29 mi (570.18 km) |
| Cape Girardeau to Canton (Illinois) | 226.19 mi (364.02 km) |
| Cape Girardeau to Canton (Mississippi) | 326.76 mi (525.87 km) |
| Cape Girardeau to Canton (Ohio) | 501.24 mi (806.66 km) |
| Cape Girardeau to Canyon (Texas) | 707.34 mi (1,138.35 km) |
| Cape Girardeau to Canyon Lake (California) | 1,572.46 mi (2,530.63 km) |
| Cape Girardeau to Canyon Lake (Texas) | 716.74 mi (1,153.48 km) |
| Cape Girardeau to Cape Coral (Florida) | 859.29 mi (1,382.89 km) |
| Cape Girardeau to Carbondale (Illinois) | 33.86 mi (54.49 km) |
| Cape Girardeau to Carlisle (Pennsylvania) | 694.36 mi (1,117.47 km) |
| Cape Girardeau to Carlsbad (California) | 1,585.50 mi (2,551.61 km) |
