| Cape Girardeau to Chantilly (Virginia) | 667.11 mi (1,073.61 km) |
| Cape Girardeau to Chaparral (New Mexico) | 1,022.23 mi (1,645.11 km) |
| Cape Girardeau to Chapel Hill (North Carolina) | 590.88 mi (950.94 km) |
| Cape Girardeau to Charleston (Illinois) | 167.76 mi (269.98 km) |
| Cape Girardeau to Charleston (South Carolina) | 624.52 mi (1,005.06 km) |
| Cape Girardeau to Charleston (West Virginia) | 438.38 mi (705.50 km) |
| Cape Girardeau to Charlotte (North Carolina) | 507.35 mi (816.50 km) |
| Cape Girardeau to Charlottesville (Virginia) | 607.33 mi (977.41 km) |
| Cape Girardeau to Chaska (Minnesota) | 559.65 mi (900.67 km) |
| Cape Girardeau to Chatham (Illinois) | 163.39 mi (262.94 km) |
| Cape Girardeau to Chattanooga (Tennessee) | 286.07 mi (460.39 km) |
| Cape Girardeau to Cheat Lake (West Virginia) | 549.10 mi (883.69 km) |
| Cape Girardeau to Chelsea (Alabama) | 321.01 mi (516.62 km) |
| Cape Girardeau to Chelsea (Massachusetts) | 1,041.03 mi (1,675.38 km) |
| Cape Girardeau to Cheney (Washington) | 1,581.41 mi (2,545.04 km) |
