| Cape Girardeau to Cicero (Illinois) | 327.56 mi (527.16 km) |
| Cape Girardeau to Cimarron Hills (Colorado) | 829.29 mi (1,334.62 km) |
| Cape Girardeau to Cincinnati (Ohio) | 301.99 mi (486.01 km) |
| Cape Girardeau to Cinco Ranch (Texas) | 633.07 mi (1,018.82 km) |
| Cape Girardeau to Circleville (Ohio) | 391.89 mi (630.68 km) |
| Cape Girardeau to Citrus (California) | 1,598.47 mi (2,572.49 km) |
| Cape Girardeau to Citrus Heights (California) | 1,721.44 mi (2,770.39 km) |
| Cape Girardeau to Citrus Park (Florida) | 756.35 mi (1,217.23 km) |
| Cape Girardeau to Claiborne (Louisiana) | 362.03 mi (582.63 km) |
| Cape Girardeau to Claremont (California) | 1,588.73 mi (2,556.81 km) |
| Cape Girardeau to Claremont (New Hampshire) | 996.65 mi (1,603.96 km) |
| Cape Girardeau to Claremore (Oklahoma) | 341.59 mi (549.74 km) |
| Cape Girardeau to Clarksburg (Maryland) | 679.31 mi (1,093.25 km) |
| Cape Girardeau to Clarksburg (West Virginia) | 518.83 mi (834.98 km) |
| Cape Girardeau to Clarksdale (Mississippi) | 222.72 mi (358.43 km) |
