| Cape Girardeau to Clarkston (Georgia) | 384.39 mi (618.61 km) |
| Cape Girardeau to Clarksville (Indiana) | 218.45 mi (351.56 km) |
| Cape Girardeau to Clarksville (Tennessee) | 132.79 mi (213.71 km) |
| Cape Girardeau to Clawson (Michigan) | 495.39 mi (797.25 km) |
| Cape Girardeau to Clay (Alabama) | 299.89 mi (482.63 km) |
| Cape Girardeau to Clayton (California) | 1,762.97 mi (2,837.23 km) |
| Cape Girardeau to Clayton (Missouri) | 101.24 mi (162.94 km) |
| Cape Girardeau to Clayton (North Carolina) | 627.25 mi (1,009.46 km) |
| Cape Girardeau to Clayton (Ohio) | 333.12 mi (536.11 km) |
| Cape Girardeau to Clearfield (Utah) | 1,227.22 mi (1,975.02 km) |
| Cape Girardeau to Clearlake (California) | 1,791.15 mi (2,882.57 km) |
| Cape Girardeau to Clearwater (Florida) | 755.84 mi (1,216.41 km) |
| Cape Girardeau to Cleburne (Texas) | 561.45 mi (903.57 km) |
| Cape Girardeau to Clemmons (North Carolina) | 515.79 mi (830.08 km) |
| Cape Girardeau to Clemson (South Carolina) | 418.43 mi (673.40 km) |
