| Cape Girardeau to Cloverly (Maryland) | 692.50 mi (1,114.48 km) |
| Cape Girardeau to Clovis (California) | 1,653.96 mi (2,661.79 km) |
| Cape Girardeau to Clovis (New Mexico) | 787.84 mi (1,267.91 km) |
| Cape Girardeau to Clute (Texas) | 664.25 mi (1,069.00 km) |
| Cape Girardeau to Coachella (California) | 1,510.93 mi (2,431.61 km) |
| Cape Girardeau to Coalinga (California) | 1,698.08 mi (2,732.80 km) |
| Cape Girardeau to Coamo (Puerto Rico) | 1,933.68 mi (3,111.96 km) |
| Cape Girardeau to Coatesville (Pennsylvania) | 763.23 mi (1,228.29 km) |
| Cape Girardeau to Cockeysville (Maryland) | 715.38 mi (1,151.29 km) |
| Cape Girardeau to Cocoa (Florida) | 799.83 mi (1,287.20 km) |
| Cape Girardeau to Cocoa Beach (Florida) | 807.71 mi (1,299.89 km) |
| Cape Girardeau to Coconut Creek (Florida) | 939.03 mi (1,511.23 km) |
| Cape Girardeau to Coeur d'Alene (Idaho) | 1,550.67 mi (2,495.56 km) |
| Cape Girardeau to Cohoes (New York) | 917.61 mi (1,476.75 km) |
| Cape Girardeau to Cold Springs (Nevada) | 1,645.04 mi (2,647.44 km) |
