| Cape Girardeau to Columbia (Illinois) | 86.96 mi (139.95 km) |
| Cape Girardeau to Columbia (Maryland) | 700.73 mi (1,127.71 km) |
| Cape Girardeau to Columbia (Missouri) | 188.13 mi (302.77 km) |
| Cape Girardeau to Columbia (Pennsylvania) | 728.71 mi (1,172.75 km) |
| Cape Girardeau to Columbia (South Carolina) | 535.61 mi (861.97 km) |
| Cape Girardeau to Columbia (Tennessee) | 181.81 mi (292.59 km) |
| Cape Girardeau to Columbia Heights (Minnesota) | 567.79 mi (913.78 km) |
| Cape Girardeau to Columbine (Colorado) | 852.73 mi (1,372.33 km) |
| Cape Girardeau to Columbus (Georgia) | 424.63 mi (683.37 km) |
| Cape Girardeau to Columbus (Indiana) | 237.10 mi (381.58 km) |
| Cape Girardeau to Columbus (Mississippi) | 270.56 mi (435.42 km) |
| Cape Girardeau to Columbus (Nebraska) | 504.32 mi (811.63 km) |
| Cape Girardeau to Columbus (Ohio) | 399.87 mi (643.53 km) |
| Cape Girardeau to Commack (New York) | 904.97 mi (1,456.41 km) |
| Cape Girardeau to Commerce (California) | 1,615.23 mi (2,599.46 km) |
