| Cape Girardeau to Cookeville (Tennessee) | 238.14 mi (383.25 km) |
| Cape Girardeau to Coolidge (Arizona) | 1,274.40 mi (2,050.95 km) |
| Cape Girardeau to Coon Rapids (Minnesota) | 577.08 mi (928.72 km) |
| Cape Girardeau to Cooper City (Florida) | 949.13 mi (1,527.48 km) |
| Cape Girardeau to Coos Bay (Oregon) | 1,859.17 mi (2,992.04 km) |
| Cape Girardeau to Copiague (New York) | 897.27 mi (1,444.02 km) |
| Cape Girardeau to Coppell (Texas) | 515.94 mi (830.32 km) |
| Cape Girardeau to Copperas Cove (Texas) | 640.47 mi (1,030.74 km) |
| Cape Girardeau to Coral Gables (Florida) | 969.62 mi (1,560.46 km) |
| Cape Girardeau to Coral Springs (Florida) | 937.06 mi (1,508.06 km) |
| Cape Girardeau to Coral Terrace (Florida) | 966.02 mi (1,554.66 km) |
| Cape Girardeau to Coralville (Iowa) | 322.02 mi (518.24 km) |
| Cape Girardeau to Coram (New York) | 919.70 mi (1,480.11 km) |
| Cape Girardeau to Corcoran (California) | 1,657.25 mi (2,667.09 km) |
| Cape Girardeau to Cordele (Georgia) | 494.99 mi (796.61 km) |
