| Cape Girardeau to Corinth (Mississippi) | 173.41 mi (279.07 km) |
| Cape Girardeau to Corinth (Texas) | 512.08 mi (824.11 km) |
| Cape Girardeau to Cornelius (North Carolina) | 498.91 mi (802.91 km) |
| Cape Girardeau to Cornelius (Oregon) | 1,810.50 mi (2,913.72 km) |
| Cape Girardeau to Corning (New York) | 742.68 mi (1,195.23 km) |
| Cape Girardeau to Corona (California) | 1,585.62 mi (2,551.81 km) |
| Cape Girardeau to Coronado (California) | 1,589.03 mi (2,557.30 km) |
| Cape Girardeau to Corpus Christi (Texas) | 803.04 mi (1,292.37 km) |
| Cape Girardeau to Corsicana (Texas) | 533.03 mi (857.84 km) |
| Cape Girardeau to Cortland (New York) | 796.11 mi (1,281.21 km) |
| Cape Girardeau to Corvallis (Oregon) | 1,815.52 mi (2,921.80 km) |
| Cape Girardeau to Coshocton (Ohio) | 462.45 mi (744.23 km) |
| Cape Girardeau to Costa Mesa (California) | 1,608.70 mi (2,588.95 km) |
| Cape Girardeau to Coto de Caza (California) | 1,592.15 mi (2,562.31 km) |
| Cape Girardeau to Cottage Grove (Minnesota) | 547.30 mi (880.79 km) |
