| Cape Girardeau to Crest Hill (Illinois) | 304.38 mi (489.85 km) |
| Cape Girardeau to Crestview (Florida) | 484.46 mi (779.66 km) |
| Cape Girardeau to Crestwood (Illinois) | 314.80 mi (506.62 km) |
| Cape Girardeau to Crestwood (Missouri) | 96.96 mi (156.04 km) |
| Cape Girardeau to Creve Coeur (Missouri) | 105.01 mi (169.00 km) |
| Cape Girardeau to Crofton (Maryland) | 708.90 mi (1,140.86 km) |
| Cape Girardeau to Crossville (Tennessee) | 268.11 mi (431.48 km) |
| Cape Girardeau to Crowley (Louisiana) | 516.02 mi (830.46 km) |
| Cape Girardeau to Crowley (Texas) | 549.23 mi (883.90 km) |
| Cape Girardeau to Crown Point (Indiana) | 307.17 mi (494.34 km) |
| Cape Girardeau to Crystal (Minnesota) | 569.10 mi (915.88 km) |
| Cape Girardeau to Crystal Lake (Illinois) | 346.25 mi (557.24 km) |
| Cape Girardeau to Cudahy (California) | 1,617.58 mi (2,603.25 km) |
| Cape Girardeau to Cudahy (Wisconsin) | 399.54 mi (643.00 km) |
| Cape Girardeau to Cullman (Alabama) | 264.77 mi (426.11 km) |
