| Cape Girardeau to Dardenne Prairie (Missouri) | 118.51 mi (190.73 km) |
| Cape Girardeau to Darien (Illinois) | 317.66 mi (511.23 km) |
| Cape Girardeau to Davenport (Iowa) | 298.59 mi (480.54 km) |
| Cape Girardeau to Davidson (North Carolina) | 501.71 mi (807.43 km) |
| Cape Girardeau to Davie (Florida) | 947.21 mi (1,524.38 km) |
| Cape Girardeau to Davis (California) | 1,746.68 mi (2,811.01 km) |
| Cape Girardeau to Dayton (Nevada) | 1,625.43 mi (2,615.88 km) |
| Cape Girardeau to Dayton (Ohio) | 336.05 mi (540.82 km) |
| Cape Girardeau to Daytona Beach (Florida) | 743.01 mi (1,195.76 km) |
| Cape Girardeau to De Pere (Wisconsin) | 497.96 mi (801.39 km) |
| Cape Girardeau to De Witt (New York) | 812.52 mi (1,307.63 km) |
| Cape Girardeau to Dearborn (Michigan) | 482.32 mi (776.21 km) |
| Cape Girardeau to Dearborn Heights (Michigan) | 480.14 mi (772.71 km) |
| Cape Girardeau to DeBary (Florida) | 751.94 mi (1,210.12 km) |
| Cape Girardeau to Decatur (Alabama) | 237.54 mi (382.29 km) |
