| Cape Girardeau to Decatur (Georgia) | 383.79 mi (617.64 km) |
| Cape Girardeau to Decatur (Illinois) | 179.04 mi (288.14 km) |
| Cape Girardeau to Deer Park (New York) | 901.99 mi (1,451.62 km) |
| Cape Girardeau to Deer Park (Texas) | 615.91 mi (991.22 km) |
| Cape Girardeau to Deerfield (Illinois) | 347.45 mi (559.17 km) |
| Cape Girardeau to Deerfield Beach (Florida) | 939.54 mi (1,512.05 km) |
| Cape Girardeau to Defiance (Ohio) | 390.22 mi (628.00 km) |
| Cape Girardeau to DeForest (Wisconsin) | 409.14 mi (658.44 km) |
| Cape Girardeau to DeKalb (Illinois) | 322.15 mi (518.45 km) |
| Cape Girardeau to Del Aire (California) | 1,628.73 mi (2,621.19 km) |
| Cape Girardeau to Del City (Oklahoma) | 456.74 mi (735.05 km) |
| Cape Girardeau to Del Rio (Texas) | 852.03 mi (1,371.21 km) |
| Cape Girardeau to DeLand (Florida) | 745.54 mi (1,199.83 km) |
| Cape Girardeau to Delano (California) | 1,645.64 mi (2,648.40 km) |
| Cape Girardeau to Delaware (Ohio) | 405.05 mi (651.87 km) |
