| Cape Girardeau to Delhi (California) | 1,706.16 mi (2,745.80 km) |
| Cape Girardeau to Delray Beach (Florida) | 932.23 mi (1,500.27 km) |
| Cape Girardeau to Deltona (Florida) | 754.69 mi (1,214.56 km) |
| Cape Girardeau to Deming (New Mexico) | 1,087.55 mi (1,750.24 km) |
| Cape Girardeau to Denison (Texas) | 464.31 mi (747.23 km) |
| Cape Girardeau to Dent (Ohio) | 295.85 mi (476.12 km) |
| Cape Girardeau to Denton (Texas) | 512.51 mi (824.81 km) |
| Cape Girardeau to Dentsville (South Carolina) | 531.81 mi (855.87 km) |
| Cape Girardeau to Denver (Colorado) | 843.79 mi (1,357.95 km) |
| Cape Girardeau to Depew (New York) | 691.06 mi (1,112.16 km) |
| Cape Girardeau to Derby (Connecticut) | 921.69 mi (1,483.32 km) |
| Cape Girardeau to Derby (Kansas) | 422.42 mi (679.82 km) |
| Cape Girardeau to Des Moines (Iowa) | 365.17 mi (587.68 km) |
| Cape Girardeau to Des Moines (Washington) | 1,795.10 mi (2,888.93 km) |
| Cape Girardeau to Des Plaines (Illinois) | 338.06 mi (544.06 km) |
