| Cape Girardeau to Desert Hot Springs (California) | 1,527.61 mi (2,458.46 km) |
| Cape Girardeau to DeSoto (Texas) | 526.05 mi (846.59 km) |
| Cape Girardeau to Destin (Florida) | 509.58 mi (820.09 km) |
| Cape Girardeau to Destrehan (Louisiana) | 509.83 mi (820.50 km) |
| Cape Girardeau to Detroit (Michigan) | 489.77 mi (788.22 km) |
| Cape Girardeau to Diamond Bar (California) | 1,596.72 mi (2,569.67 km) |
| Cape Girardeau to Diamond Springs (California) | 1,697.42 mi (2,731.74 km) |
| Cape Girardeau to Dickinson (North Dakota) | 945.40 mi (1,521.47 km) |
| Cape Girardeau to Dickinson (Texas) | 628.42 mi (1,011.34 km) |
| Cape Girardeau to Dickson (Tennessee) | 148.96 mi (239.73 km) |
| Cape Girardeau to Difficult Run (Virginia) | 672.47 mi (1,082.23 km) |
| Cape Girardeau to Dinuba (California) | 1,642.07 mi (2,642.65 km) |
| Cape Girardeau to Discovery Bay (California) | 1,745.49 mi (2,809.09 km) |
| Cape Girardeau to Dix Hills (New York) | 901.68 mi (1,451.12 km) |
| Cape Girardeau to Dixon (California) | 1,752.37 mi (2,820.17 km) |
