| Cape Girardeau to Dixon (Illinois) | 313.23 mi (504.09 km) |
| Cape Girardeau to Dobbs Ferry (New York) | 877.18 mi (1,411.69 km) |
| Cape Girardeau to Doctor Phillips (Florida) | 770.15 mi (1,239.44 km) |
| Cape Girardeau to Dodge City (Kansas) | 573.55 mi (923.05 km) |
| Cape Girardeau to Dolton (Illinois) | 316.10 mi (508.72 km) |
| Cape Girardeau to Donna (Texas) | 917.87 mi (1,477.16 km) |
| Cape Girardeau to Dorado (Puerto Rico) | 1,917.77 mi (3,086.35 km) |
| Cape Girardeau to Doral (Florida) | 960.29 mi (1,545.44 km) |
| Cape Girardeau to Doraville (Georgia) | 378.78 mi (609.58 km) |
| Cape Girardeau to Dothan (Alabama) | 482.08 mi (775.83 km) |
| Cape Girardeau to Douglas (Arizona) | 1,208.90 mi (1,945.53 km) |
| Cape Girardeau to Douglas (Georgia) | 553.70 mi (891.09 km) |
| Cape Girardeau to Douglasville (Georgia) | 367.92 mi (592.11 km) |
| Cape Girardeau to Dover (Delaware) | 771.76 mi (1,242.04 km) |
| Cape Girardeau to Dover (New Hampshire) | 1,062.32 mi (1,709.64 km) |
