| Cape Girardeau to Dover (New Jersey) | 840.14 mi (1,352.07 km) |
| Cape Girardeau to Dover (Ohio) | 487.67 mi (784.84 km) |
| Cape Girardeau to Downers Grove (Illinois) | 320.51 mi (515.81 km) |
| Cape Girardeau to Downey (California) | 1,615.23 mi (2,599.46 km) |
| Cape Girardeau to Dranesville (Virginia) | 671.94 mi (1,081.39 km) |
| Cape Girardeau to Draper (Utah) | 1,215.70 mi (1,956.48 km) |
| Cape Girardeau to Drexel Heights (Arizona) | 1,268.13 mi (2,040.85 km) |
| Cape Girardeau to Drexel Hill (Pennsylvania) | 789.82 mi (1,271.09 km) |
| Cape Girardeau to Duarte (California) | 1,600.98 mi (2,576.52 km) |
| Cape Girardeau to Dublin (California) | 1,763.55 mi (2,838.16 km) |
| Cape Girardeau to Dublin (Georgia) | 499.73 mi (804.24 km) |
| Cape Girardeau to Dublin (Ohio) | 396.12 mi (637.49 km) |
| Cape Girardeau to Dubuque (Iowa) | 363.66 mi (585.25 km) |
| Cape Girardeau to Duluth (Georgia) | 379.91 mi (611.41 km) |
| Cape Girardeau to Duluth (Minnesota) | 667.10 mi (1,073.60 km) |
