| Cape Girardeau to Dumas (Texas) | 694.92 mi (1,118.37 km) |
| Cape Girardeau to Dumont (New Jersey) | 869.97 mi (1,400.08 km) |
| Cape Girardeau to Duncan (Oklahoma) | 505.24 mi (813.10 km) |
| Cape Girardeau to Duncanville (Texas) | 526.17 mi (846.79 km) |
| Cape Girardeau to Dundalk (Maryland) | 720.68 mi (1,159.82 km) |
| Cape Girardeau to Dunedin (Florida) | 751.88 mi (1,210.04 km) |
| Cape Girardeau to Dunkirk (New York) | 648.49 mi (1,043.65 km) |
| Cape Girardeau to Dunmore (Pennsylvania) | 796.31 mi (1,281.53 km) |
| Cape Girardeau to Dunwoody (Georgia) | 375.44 mi (604.21 km) |
| Cape Girardeau to Durango (Colorado) | 1,005.39 mi (1,618.02 km) |
| Cape Girardeau to Durant (Oklahoma) | 446.63 mi (718.78 km) |
| Cape Girardeau to Durham (North Carolina) | 597.61 mi (961.75 km) |
| Cape Girardeau to Dyer (Indiana) | 309.28 mi (497.73 km) |
| Cape Girardeau to Dyersburg (Tennessee) | 87.94 mi (141.53 km) |
| Cape Girardeau to Eagan (Minnesota) | 551.41 mi (887.40 km) |
