| Cape Girardeau to Eagle (Idaho) | 1,469.61 mi (2,365.11 km) |
| Cape Girardeau to Eagle Mountain (Utah) | 1,223.00 mi (1,968.23 km) |
| Cape Girardeau to Eagle Pass (Texas) | 866.89 mi (1,395.12 km) |
| Cape Girardeau to Easley (South Carolina) | 425.88 mi (685.38 km) |
| Cape Girardeau to East Bakersfield (California) | 1,635.75 mi (2,632.49 km) |
| Cape Girardeau to East Bethel (Minnesota) | 586.94 mi (944.59 km) |
| Cape Girardeau to East Chicago (Indiana) | 319.91 mi (514.84 km) |
| Cape Girardeau to East Cleveland (Ohio) | 515.86 mi (830.19 km) |
| Cape Girardeau to East Glenville (New York) | 909.28 mi (1,463.35 km) |
| Cape Girardeau to East Grand Rapids (Michigan) | 441.66 mi (710.78 km) |
| Cape Girardeau to East Hemet (California) | 1,553.97 mi (2,500.87 km) |
| Cape Girardeau to East Highland Park (Virginia) | 667.57 mi (1,074.34 km) |
| Cape Girardeau to East Honolulu (Hawaii) | 4,164.69 mi (6,702.41 km) |
| Cape Girardeau to East Islip (New York) | 908.51 mi (1,462.11 km) |
| Cape Girardeau to East Lake (Florida) | 749.68 mi (1,206.49 km) |
