| Cape Girardeau to East Lake-Orient Park (Florida) | 767.04 mi (1,234.44 km) |
| Cape Girardeau to East Lansing (Michigan) | 461.58 mi (742.85 km) |
| Cape Girardeau to East Los Angeles (California) | 1,615.46 mi (2,599.84 km) |
| Cape Girardeau to East Massapequa (New York) | 895.05 mi (1,440.45 km) |
| Cape Girardeau to East Meadow (New York) | 889.18 mi (1,430.99 km) |
| Cape Girardeau to East Milton (Florida) | 485.75 mi (781.73 km) |
| Cape Girardeau to East Moline (Illinois) | 294.15 mi (473.39 km) |
| Cape Girardeau to East Niles (California) | 1,633.15 mi (2,628.31 km) |
| Cape Girardeau to East Northport (New York) | 903.36 mi (1,453.82 km) |
| Cape Girardeau to East Orange (New Jersey) | 856.26 mi (1,378.01 km) |
| Cape Girardeau to East Palo Alto (California) | 1,779.27 mi (2,863.46 km) |
| Cape Girardeau to East Patchogue (New York) | 919.62 mi (1,479.99 km) |
| Cape Girardeau to East Peoria (Illinois) | 232.34 mi (373.92 km) |
| Cape Girardeau to East Point (Georgia) | 381.04 mi (613.22 km) |
| Cape Girardeau to East Providence (Rhode Island) | 1,015.89 mi (1,634.93 km) |
