| Cape Girardeau to East Rancho Dominguez (California) | 1,619.62 mi (2,606.53 km) |
| Cape Girardeau to East Renton Highlands (Washington) | 1,785.60 mi (2,873.64 km) |
| Cape Girardeau to East Ridge (Tennessee) | 289.67 mi (466.18 km) |
| Cape Girardeau to East Riverdale (Maryland) | 696.19 mi (1,120.41 km) |
| Cape Girardeau to East San Gabriel (California) | 1,608.91 mi (2,589.30 km) |
| Cape Girardeau to East St. Louis (Illinois) | 95.35 mi (153.45 km) |
| Cape Girardeau to East Wenatchee (Washington) | 1,702.41 mi (2,739.76 km) |
| Cape Girardeau to Eastern Goleta Valley (California) | 1,696.58 mi (2,730.38 km) |
| Cape Girardeau to Eastlake (Ohio) | 526.93 mi (848.02 km) |
| Cape Girardeau to Eastmont (Washington) | 1,795.87 mi (2,890.17 km) |
| Cape Girardeau to Easton (Maryland) | 740.27 mi (1,191.36 km) |
| Cape Girardeau to Easton (Pennsylvania) | 803.40 mi (1,292.95 km) |
| Cape Girardeau to Eastpointe (Michigan) | 499.47 mi (803.82 km) |
| Cape Girardeau to Eastvale (California) | 1,584.49 mi (2,549.99 km) |
| Cape Girardeau to Eatontown (New Jersey) | 858.60 mi (1,381.79 km) |
