| Cape Girardeau to Eau Claire (Wisconsin) | 528.47 mi (850.48 km) |
| Cape Girardeau to Echelon (New Jersey) | 804.96 mi (1,295.45 km) |
| Cape Girardeau to Eden (North Carolina) | 545.07 mi (877.20 km) |
| Cape Girardeau to Eden Prairie (Minnesota) | 558.84 mi (899.37 km) |
| Cape Girardeau to Edgewater (Florida) | 761.91 mi (1,226.17 km) |
| Cape Girardeau to Edgewater (New Jersey) | 869.24 mi (1,398.91 km) |
| Cape Girardeau to Edgewood (Maryland) | 732.42 mi (1,178.72 km) |
| Cape Girardeau to Edgewood (Washington) | 1,791.56 mi (2,883.24 km) |
| Cape Girardeau to Edina (Minnesota) | 559.72 mi (900.78 km) |
| Cape Girardeau to Edinburg (Texas) | 910.96 mi (1,466.05 km) |
| Cape Girardeau to Edmond (Oklahoma) | 450.76 mi (725.42 km) |
| Cape Girardeau to Edmonds (Washington) | 1,802.45 mi (2,900.77 km) |
| Cape Girardeau to Edwards (Colorado) | 935.07 mi (1,504.85 km) |
| Cape Girardeau to Edwardsville (Illinois) | 104.96 mi (168.92 km) |
| Cape Girardeau to Effingham (Illinois) | 136.50 mi (219.67 km) |
