| Cape Girardeau to Eggertsville (New York) | 688.55 mi (1,108.11 km) |
| Cape Girardeau to Egypt Lake-Leto (Florida) | 761.40 mi (1,225.35 km) |
| Cape Girardeau to El Cajon (California) | 1,574.94 mi (2,534.62 km) |
| Cape Girardeau to El Campo (Texas) | 681.07 mi (1,096.07 km) |
| Cape Girardeau to El Centro (California) | 1,498.46 mi (2,411.54 km) |
| Cape Girardeau to El Cerrito (California) | 1,783.25 mi (2,869.86 km) |
| Cape Girardeau to El Dorado (Arkansas) | 332.55 mi (535.19 km) |
| Cape Girardeau to El Dorado (Kansas) | 401.33 mi (645.88 km) |
| Cape Girardeau to El Dorado Hills (California) | 1,708.81 mi (2,750.06 km) |
| Cape Girardeau to El Mirage (Arizona) | 1,303.61 mi (2,097.96 km) |
| Cape Girardeau to El Monte (California) | 1,606.97 mi (2,586.17 km) |
| Cape Girardeau to El Paso (Texas) | 1,029.41 mi (1,656.67 km) |
| Cape Girardeau to El Paso de Robles (California) | 1,723.76 mi (2,774.12 km) |
| Cape Girardeau to El Reno (Oklahoma) | 482.85 mi (777.07 km) |
| Cape Girardeau to El Segundo (California) | 1,630.51 mi (2,624.06 km) |
