| Cape Girardeau to El Sobrante (California) | 1,579.77 mi (2,542.40 km) |
| Cape Girardeau to Eldersburg (Maryland) | 697.56 mi (1,122.61 km) |
| Cape Girardeau to Elfers (Florida) | 743.00 mi (1,195.74 km) |
| Cape Girardeau to Elgin (Illinois) | 333.17 mi (536.18 km) |
| Cape Girardeau to Elizabeth (New Jersey) | 856.00 mi (1,377.60 km) |
| Cape Girardeau to Elizabeth City (North Carolina) | 739.83 mi (1,190.64 km) |
| Cape Girardeau to Elizabethton (Tennessee) | 410.45 mi (660.55 km) |
| Cape Girardeau to Elizabethtown (Kentucky) | 203.63 mi (327.71 km) |
| Cape Girardeau to Elizabethtown (Pennsylvania) | 724.88 mi (1,166.58 km) |
| Cape Girardeau to Elk City (Oklahoma) | 564.85 mi (909.04 km) |
| Cape Girardeau to Elk Grove (California) | 1,729.00 mi (2,782.55 km) |
| Cape Girardeau to Elk Grove Village (Illinois) | 334.95 mi (539.06 km) |
| Cape Girardeau to Elk Plain (Washington) | 1,793.09 mi (2,885.69 km) |
| Cape Girardeau to Elk River (Minnesota) | 591.69 mi (952.23 km) |
| Cape Girardeau to Elkhart (Indiana) | 358.23 mi (576.52 km) |
