| Cape Girardeau to Elkhorn (Wisconsin) | 374.29 mi (602.36 km) |
| Cape Girardeau to Elko (Nevada) | 1,421.24 mi (2,287.26 km) |
| Cape Girardeau to Elkridge (Maryland) | 706.85 mi (1,137.57 km) |
| Cape Girardeau to Elkton (Maryland) | 759.24 mi (1,221.88 km) |
| Cape Girardeau to Ellensburg (Washington) | 1,708.41 mi (2,749.41 km) |
| Cape Girardeau to Ellicott City (Maryland) | 702.67 mi (1,130.84 km) |
| Cape Girardeau to Elmhurst (Illinois) | 328.35 mi (528.42 km) |
| Cape Girardeau to Elmira (New York) | 752.99 mi (1,211.81 km) |
| Cape Girardeau to Elmont (New York) | 881.38 mi (1,418.44 km) |
| Cape Girardeau to Elmwood Park (Illinois) | 331.85 mi (534.05 km) |
| Cape Girardeau to Elmwood Park (New Jersey) | 862.87 mi (1,388.66 km) |
| Cape Girardeau to Elon (North Carolina) | 562.71 mi (905.60 km) |
| Cape Girardeau to Eloy (Arizona) | 1,282.93 mi (2,064.68 km) |
| Cape Girardeau to Elwood (New York) | 902.14 mi (1,451.86 km) |
| Cape Girardeau to Elyria (Ohio) | 487.06 mi (783.84 km) |
