| Cape Girardeau to Emeryville (California) | 1,783.62 mi (2,870.46 km) |
| Cape Girardeau to Emmaus (Pennsylvania) | 787.02 mi (1,266.59 km) |
| Cape Girardeau to Emporia (Kansas) | 369.56 mi (594.76 km) |
| Cape Girardeau to Encinitas (California) | 1,585.92 mi (2,552.29 km) |
| Cape Girardeau to Endicott (New York) | 788.77 mi (1,269.41 km) |
| Cape Girardeau to Endwell (New York) | 791.28 mi (1,273.44 km) |
| Cape Girardeau to Englewood (Colorado) | 849.16 mi (1,366.60 km) |
| Cape Girardeau to Englewood (Florida) | 828.85 mi (1,333.91 km) |
| Cape Girardeau to Englewood (New Jersey) | 870.18 mi (1,400.42 km) |
| Cape Girardeau to Englewood (Ohio) | 333.98 mi (537.48 km) |
| Cape Girardeau to Enid (Oklahoma) | 463.49 mi (745.92 km) |
| Cape Girardeau to Ennis (Texas) | 528.58 mi (850.67 km) |
| Cape Girardeau to Ensley (Florida) | 486.73 mi (783.32 km) |
| Cape Girardeau to Enterprise (Alabama) | 464.45 mi (747.45 km) |
| Cape Girardeau to Enterprise (Nevada) | 1,421.16 mi (2,287.13 km) |
